Plinest® Polynucleotides, the latest powerhouse in skin rejuvenation that’s transforming tired, dehydrated, and damaged skin.



With reduced risks, fewer complications, and undeniably good results, polynucleotides are next generation biostimulators that go beyond hydration. They stimulate fibroblasts, leading to increased collagen and elastin production, reduced inflammation, improvement in tear trough complaints, diminished dark under-eye circles, and overall tighter, healthier looking skin.
Introducing Plinest® Polynucleotides: The Future of Skin Rejuvenation
Here at Three Medical Aesthetics, we are delighted to have introduced Plinest® Polynucleotides, an innovative product designed to rejuvenate and revitalise your skin. As part of our commitment to cutting-edge, non-invasive treatments, Plinest® Polynucleotides complement our existing services, providing you with even more options to achieve your skin health goals.
What Are Plinest® Polynucleotides & How Do They Work?
Think of polynucleotides as nutrition for your skin cells, helping them repair, rebuild, and rejuvenate naturally. Unlike traditional fillers, they don’t add volume - instead, they stimulate deep skin renewal for long-term, visible results.
Plinest® Polynucleotides
Created by Mastelli, Plinest® is our polynucleotide of choice across our clinics. Obtained through High Purification Technology (HPT) featuring a high degree of purification and safety, it utilises purified DNA fragments extracted from trout fish gonads to stimulate skin regeneration. These polynucleotides promote fibroblast activity, enhance collagen production, and improve skin elasticity, resulting in firmer, healthier and hydrated skin.
Key Benefits of Plinest® Polynucleotides
- Deep Hydration: Intensely moisturises and improves skin texture, reducing the appearance of fine lines.
- Enhanced Elasticity: Boosts collagen production, restoring skin firmness and bounce.
- Natural Rejuvenation: Supports the skin’s own repair process without altering facial expressions or volume.
- Minimal Downtime: A quick, convenient treatment with little to no recovery time.
Are Polynucleotides Made from Fish DNA?

Yes - polynucleotides are derived from purified fish DNA, typically sourced from trout sperm. These DNA fragments closely resemble human DNA, making them highly biocompatible and effective as a biostimulator.
Once purified and filtered, polynucleotides trigger the body’s natural repair mechanisms, increasing fibroblast activity, collagen production, and overall skin health. You’ll notice an immediate improvement in skin structure, with results continuing to improve over time.
Polynucleotides vs. Dermal Fillers
Unlike hyaluronic acid-based fillers, polynucleotides don’t add volume. Instead, they focus on repairing and rejuvenating the skin from within, making them an excellent alternative for those who experience puffiness with traditional tear trough fillers.
How Much Does Polynucleotide Treatment Cost?
- Cost: Treatments start from £300 per area/per session
- Sessions Required: Typically, 2-3 treatments (spaced 2-3 weeks apart)
- Where Can They Be Used? Polynucleotides can be injected into the face, neck, décolleté, and eye area, making them highly versatile for different skin concerns.
Integrating Plinest® Polynucleotides with Other Treatments for Maximum Results
To enhance the effects of polynucleotides, we recommend combining them with other advanced aesthetic treatments:
- Microneedling – Boosts collagen stimulation, improving skin texture and tone.
- Dermal Fillers – While Plinest focuses on skin quality, fillers restore lost volume for a more youthful look.
- Chemical Peels – Helps with pigmentation issues and enhances skin resurfacing.
At Three Medical Aesthetics, we’ll create a personalised treatment plan to help you achieve your skin health and aesthetic goals with the best combination of treatments.
Who Can Benefit from Polynucleotide Treatment?
Polynucleotides are ideal for those who want to restore skin health and vitality naturally. They are especially beneficial for those who wish to target any of the following;
- Fine lines & wrinkles
- Loss of skin elasticity
- Dull or dehydrated skin
- Early signs of ageing
- Acne scarring & inflammation
- Sun damage & pigmentation issues
The best way to determine if this treatment is right for you is through a face-to-face consultation with our expert practitioner.
Your Journey to Healthier, More Youthful Looking Skin Starts Here
Plinest® polynucleotide treatments represent a significant advancement in aesthetic medicine, offering a natural, effective solution for skin rejuvenation and repair. By integrating this revolutionary treatment into our clinic, Three Medical Aesthetics continues to provide the most cutting-edge, results-driven treatments for our patients.
Book Your Consultation Today!
Whether you're looking to refresh your skin, improve elasticity, or find an alternative to fillers, our expert team is here to help.
Your path to confidence starts now! Book directly via Glowday if you know what you need or schedule a consultation to explore your options